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An expert panel hosted by
Sequencing immune-based therapies in B-cell malignancies
with Ulric Jäger, Sagar Lonial, and Krina Patel
Saturday, June 15 | 18:00-19:30 CEST
Register nowThis independent education activity is sponsored by Bristol Myers Squibb. All content is developed independently by the faculty. Funders are allowed no direct influence on the content of this activity.
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On April 15, 2024, it was announced that the phase III STARGLO trial (NCT04408638) assessing glofitamab, a CD20 × CD3 T-cell engaging bispecific antibody, plus gemcitabine and oxaliplatin vs rituximab plus gemcitabine and oxaliplatin met its primary endpoint of overall survival. Glofitamab in combination with gemcitabine and oxaliplatin demonstrated a statistically significant improvement in overall survival for patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who received at least one prior line of therapy and were not candidates for autologous stem cell transplant. The safety profile of the combination was consistent with the known safety profiles of the individual treatments.
Glofitamab previously received accelerated approval from the U.S. Food and Drug Administration (FDA) and conditional marketing authorization from the European Commission (EC) for the treatment of patients with R/R DLBCL after two or more lines of systemic therapy.
These encouraging data show that glofitamab in combination with gemcitabine and oxaliplatin has the potential to improve survival outcomes in earlier lines of treatment for patients with R/R DLBCL, who currently have limited options.
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