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2023-12-28T10:10:38.000Z

SWOG1826: What are the key takeaways?

Dec 28, 2023
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Learning objective: After reading this article, learners will be able to cite a new clinical development in treatments for older patients (≥60 years) with advanced-stage hodgkin lymphoma.

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During the 65th American Society of Hematology (ASH) Annual Meeting and Exposition, the Lymphoma Hub spoke to Sarah Rutherford, Weill Cornell Medicine, New York, US. We asked, SWOG1826: What are the key takeaways?

SWOG1826: What are the key takeaways?

Firstly, Rutherford discusses key findings from SWOGS1826 which investigated nivolumab-AVD (N-AVD) versus brentuximab vedotin-AVD (Bv-AVD) in older patients (≥60 years) with advanced Hodgkin lymphoma. She highlights the positive tolerability results for N-AVD therapy compared with Bv-AVD, citing fewer adverse events with N-AVD, such as nausea, diarrhea, and sepsis infections. She then outlines the promising efficacy data, with 93% of patients in the N-AVD arm achieving progression-free survival, compared with 64% in the Bv-AVD arm.

In conclusion, N-AVD has the potential to be a standard-of-care treatment option for older patients with advanced Hodgkin lymphoma; however, further follow-up is warranted.

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