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CD19-directed chimeric antigen receptor (CAR) T-cell therapies have transformed the treatment of patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL). However, relapse remains a significant challenge, with antigen escape through loss or downregulation of CD19 expression representing an important mechanism of resistance. Tandem CAR T-cell therapies targeting both CD19 and CD20 are being investigated as a strategy to address this limitation and potentially improve the durability of response.
The Lymphoma Hub spoke with Peter Borchmann, Nirav Shah, and Ulrich Jäger about the rationale for tandem CAR T-cell therapies, emerging clinical evidence, and the potential future role of these approaches in the treatment of R/R LBCL.
The Lymphoma Hub was pleased to speak with Peter Borchmann, University Hospital Cologne, DE. We asked, What is the rationale for the development of tandem chimeric antigen receptor (CAR) T-cell therapies?
The Lymphoma Hub spoke to Nirav Shah, Medical College of Wisconsin, Milwaukee, US. We asked, What is the current clinical evidence for tandem chimeric antigen receptor (CAR) T-cell therapies in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL)?
The Lymphoma Hub was pleased to speak with Ulrich Jäger, Medical University of Vienna, AT. We asked, How do you see tandem CAR T-cell therapies fitting into the future treatment landscape for LBCL?
This educational resource is independently supported by Miltenyi Biomedicine. All content is developed by SES in collaboration with an expert steering committee. Funders are allowed no influence.
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This content is accurate as of the date of publication and is not updated retrospectively. Please refer to the latest available evidence, guidelines, and relevant regulatory information when making clinical decisions.
Your opinion matters
When selecting the next therapy for patients with R/R MCL after BTKi progression, what is your most important consideration?
Ulrich Jäger
Peter Borchmann
Nirav Shah