All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
Introducing
Now you can personalise
your Lymphoma Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Lymphoma & CLL Hub is an independent medical education platform, sponsored by Beigene and Roche, and supported through educational grants from Bristol Myers Squibb, Ipsen Biopharmaceuticals, Lilly, Pfizer, and Pharmacyclics LLC, an AbbVie Company and Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC View funders.
Bookmark this article
On February 2018, Professor Simon Rule from Plymouth University Medical School, UK and colleagues, in a letter to the editor of Leukemia, published the final 3-year follow-up results from the RAY phase III clinical trial (NCT01646021). This randomized, open-label study evaluated the efficacy and safety of ibrutinib versus temsirolimus for mantle cell lymphoma patients (MCL), who have previously relapsed from first-line therapy. The results of RAY indicated the superiority of ibrutinib over temsirolimus for MCL, in regards to efficacy, with ibrutinib-mediated progression-free survival (PFS) being significantly higher than that with temsirolimus (14.6 vs 6.2 months, HR 0.43, 95% CI [0.32–0.58]).
In this final follow-up analysis of the RAY phase III trial, three years post-treatment, the results were consistent to the ones observed in the primary analysis. In summary, ibrutinib led to significantly longer median PFS, OS and ORR, providing strong evidence on the sustained long-term clinical benefit of ibrunitib for primary relapsed MCL patients.
Understanding your specialty helps us to deliver the most relevant and engaging content.
Please spare a moment to share yours.
Please select or type your specialty
Your opinion matters
Subscribe to get the best content related to lymphoma & CLL delivered to your inbox