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TRANSCEND CLL 004: A post hoc analysis of characteristics associated with response to liso-cel
The phase I/II TRANSCEND CLL 004 trial (NCT03331198) assessed the efficacy and safety of lisocabtagene maraleucel (liso-cel), a chimeric antigen receptor (CAR) T-cell therapy, in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) / small lymphocytic lymphoma (SLL).1 Results from this trial showed that liso-cel was associated with an overall response rate (ORR) of 47% and a complete response (CR)/CR with incomplete count recovery (CRi) rate of 18% in the full efficacy evaluable population (n = 96).1
Results from an exploratory analysis of the TRANSCEND CLL 004 trial evaluating the correlations between pretreatment variables and response at the primary data analysis cut-off (September 29, 2022) were presented by William Wierda during the European Hematology Association (EHA) 2024 Hybrid Congress, Jun 13–16, 2024, Madrid, ES.1
This educational resource is independently supported by Bristol Myers Squibb. All content is developed by SES in collaboration with an expert steering committee; funders are allowed no influence on the content of this resource.
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In patients with R/R LBCL who progress after CAR‑T, which of the following data would most strengthen your confidence in considering BV+R2?
