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An expert panel hosted by
Sequencing immune-based therapies in B-cell malignancies
with Ulric Jäger, Sagar Lonial, and Krina Patel
Saturday, June 15 | 18:00-19:30 CEST
Register nowThis independent education activity is sponsored by Bristol Myers Squibb. All content is developed independently by the faculty. Funders are allowed no direct influence on the content of this activity.
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The phase II M13-982 trial (NCT01889186) assessed venetoclax monotherapy in patients aged ≥18 years with relapsed/refractory (R/R) or previously untreated chronic lymphocytic leukemia (CLL) with a 17p deletion (del[17p]).1 The study design and primary results have previously been reported by the Lymphoma Hub. Briefly, venetoclax was associated with an overall response rate (ORR) of 77% and was well tolerated.1 Here, we summarize the 6-year follow-up and subgroup analyses from the M13-982 trial, published by Stilgenbauer, et al.1 in Blood Advances.
Table 1. Response rates in the M13-982 trial*
Response rate, % |
Venetoclax monotherapy |
---|---|
Overall response rate |
77 |
Complete remission |
21 |
Complete remission with incomplete hematological recovery |
3 |
Partial remission |
49 |
Nodular partial remission |
4 |
Stable disease |
19 |
Progressive disease |
2 |
Not evaluable |
2 |
*Data from Stilgenbauer et al.1 |
Figure 1. Long-term survival outcomes in M13-982 trial*
CR, complete remission; CRi, CR with incomplete hematological recovery; nPR, nodular partial remission; NR, not reached; OS, overall survival; PFS, progression-free survival; PR, partial remission.
*Data from Stilgenbauer et al.1
†Response at Week 36 (±4 weeks)
Figure 2. Median PFS from month 24 by MRD status in the M13-982 and MURANO trials*
MRD, measurable residual disease; NR, not reached; PFS, progression-free survival.
*Data from Stilgenbauer et al.1
†MRD status was classified as undetectable (<10−4), low MRD positive (MRD+, 10−4 to 10–2), and high MRD+ (>10−2).
Key learnings |
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