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Visual abstract | HD21 final analysis: PET-guided BrECADD vs eBEACOPP in AS cHL
Do you know... Based on results from the HD21 trial, compared with eBEACOPP, which of the following is true of BrECADD in patients with newly diagnosed advanced-stage cHL?
The randomized, multicenter, open-label, phase III HD21 trial (NCT02661503) compared the efficacy and safety of positron emission tomography (PET)-guided brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone (BrECADD) vs escalated doses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (eBEACOPP) in 1,482 adult patients aged ≤60 years with newly diagnosed advanced-stage (AS) classical Hodgkin lymphoma (cHL).1,2 Efficacy and safety results and fertility outcomes from this trial were previously reported by the Lymphoma Hub.
Results from the final analysis of the HD21 trial, with 5 years of follow-up, were presented by Justin Ferdinandus during the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, December 6–9, 2025, Orlando, US, and are summarized below.2
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In your experience, what is the average vein-to-vein time when treating patients with DLBCL with a reimbursed CAR T-cell therapy (from apheresis to infusion)?
