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During the ASCO 2022 congress, the Lymphoma Hub was pleased to speak with Anita Kumar, Memorial Sloane Kettering Cancer Center, New York, US. We asked, What is on the horizon for the frontline treatment of mantle cell lymphoma (MCL)?
What is on the horizon for the frontline treatment of MCL?
Kumar begins by discussing the historic treatment options for patients with MCL before highlighting that, in the future, clinicians hope to utilize information on clinical and biological baseline features that patients present with, and incorporate novel targeted therapies and MRD assessments to further individualize treatment for MCL. Kumar describes how increased pathobiological understanding has led to developments in the relapsed/refractory setting; results of studies, such as SHINE, have explored this. Finally, Kumar discusses other therapeutic options and outlines adverse events and efficacy seen in the current OASIS phase III trial.
Latest advances in the treatment of mantle cell lymphoma
The current and future treatment landscape for MCL looks hopeful, with the development of new treatment regimens and novel therapeutics that offer greater efficacy, precision, and improved OS...
Efficacy and safety of ibrutinib + BR in the treatment of elderly patients with MCL: Primary analysis from SHINE III
The primary analysis of the ongoing phase III SHINE trial shows that ibrutinib + BR significantly improved PFS in elderly patients...
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