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On Sun 3rd June an oral abstract session took place at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting. Abstract 7504 was presented by Ranjana Advani, Stanford Cancer Institute, California, on the phase 1b/2 study of Hu5F9-G4 first-in-class anti-CD47 antibody (5F9). The aim of the study was to assess the safety and efficacy of 5F9 (NCT02953509).
Patients with relapsed or refractory (R/R) non-Hodgkin lymphoma (NHL) were included in the study if they had failed previous lines of therapy. The study consisted of a phase Ib dose escalation in which patients received a priming dose with 5F9 (1 mg/kg) up to a maintenance dose of 10–30 mg/kg with rituximab.
The results of the study showed that the combination of 5F9 and rituximab was well tolerated with promising clinical activity in patients with R/R FL and DLBCL. Trials are ongoing for further analysis.
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