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An expert panel hosted by
Sequencing immune-based therapies in B-cell malignancies
with Ulric Jäger, Sagar Lonial, and Krina Patel
Saturday, June 15 | 18:00-19:30 CEST
Register nowThis independent education activity is sponsored by Bristol Myers Squibb. All content is developed independently by the faculty. Funders are allowed no direct influence on the content of this activity.
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On July 14, 2020, the U.S. Food and Drug Administration (FDA) granted breakthrough therapy designation to mosunetuzumab for the treatment of adult patients with relapsed or refractory (R/R) follicular lymphoma (FL) who have received at least two prior systemic therapies.
Mosunetuzumab is a bispecific antibody targeting CD3, on the surface of T cells, and CD20, on the surface of B cells. This dual targeting redirects T cells to engage B cells, leading to the lysis and elimination of malignant cells.
The breakthrough therapy designation is based on the promising results of the phase I/Ib GO29781 trial (NCT02500407) investigating mosunetuzumab monotherapy and in combination with other agents in patients with R/R non-Hodgkin lymphoma. In the subgroup of patients with R/R FL, mosunetuzumab showed high response rates and durable complete remissions with a tolerable safety profile.
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