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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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Results from the phase III STARGLO trial (NCT04408638) of glofitamab plus gemcitabine and oxaliplatin (Glofit-GemOx) vs rituximab plus gemcitabine and oxaliplatin (R-GemOx) in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) were presented at the European Hematology Association (EHA) 2024 Hybrid Congress by Abramson.1 |
Key learnings: |
The primary endpoint of overall survival (OS) was met. |
After a median follow-up of 20.7 months, median OS was 25.5 months vs 12.9 months in the Glofit-GemOx and R-GemOx arms, respectively (hazard ratio [HR], 0.62; p = 0.006). |
Glofit-GemOx was associated with improved progression-free survival (PFS) and a higher complete response (CR) rate vs R-GemOx: median PFS was 13.8 months vs 3.6 months (HR, 0.40; p < 0.000001) and the CR rates were 58.5% vs 25.3% (p < 0.0001), respectively. |
The safety profile of Glofit-GemOx was consistent with that of the individual agents. |
Glofitamab is the first CD20xCD3 bispecific antibody to demonstrate a survival benefit in DLBCL in a randomized phase III trial. |
The efficacy data from the phase III STARGLO trial and the tolerable safety profile of Glofit-GemOx supports the use of Glofit-GemOx in the treatment of patients with R/R DLBCL. |
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