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Liso-cel for relapsed/refractory large B-cell lymphoma: Results from TRANSCEND NHL 001

Oct 14, 2020

Results from the seamless design TRANSCEND NHL 001 study highlight the encouraging clinical efficacy and safety profile of lisocabtagene maraleucel (liso-cel) in patients with relapsed or refractory (R/R) large B-cell lymphomas (LBCL).

The TRANSCEND NHL 001 study evaluated the safety and efficacy of the CD19-directed chimeric antigen receptor (CAR) T-cell product, liso-cel, across a broad cohort of patients with R/R LBCL. Since the promising data from the dose-determining portion of the trial, results from the entire patient population has been reported in The Lancet.

The full study design and key safety and efficacy results were presented at the 61st American Society of Hematology (ASH) Annual Meeting & Exposition; read more here.

  1. Abramson JS, Palomba ML, Gordon LI, et al. Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. Lancet. 2020;396(10254):839-852. DOI:  10.1016/S0140-6736(20)31366-0

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At this year’s virtual ESH Meeting, the Lymphoma Hub Satellite Symposium will evaluate treatment options in patients with R/R DLBCL. What do you think is the most promising emerging therapy in this setting?
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