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Orphan drug designation granted to DT2216 for the treatment of T-cell lymphoma
On March 14, 2022, the U.S. Food and Drug Administration (FDA) granted orphan drug designation to DT2216, a compound based on antiapoptotic protein targeted degradation technology, for the treatment of T-cell lymphoma1.
DT2216 is a first-generation compound designed to induce degradation of BCL-XL, an anti-apoptotic protein involved in malignant cell survival.1,2. This agent is currently being evaluated in a phase I clinical trial involving patients with confirmed advanced or metastatic solid tumors and hematologic malignancies that are unresponsive to currently approved treatments1.
It is hoped that DT2216 can help to address a critical unmet need for patients diagnosed with this rare form of cancer.
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What is your preferred therapy class when planning treatment for a patient with R/R DLBCL after 2 or more lines of systemic therapy ?