At this year’s European School of Haematology (ESH) 2nd How to Diagnose and Treat: Lymphoma conference, the Lymphoma Hub was proud to host a virtual Satellite Symposium on the management and treatment of patients with relapsed/refractory (R/R) lymphoma.
Astrid Pavlovsky, Fundaleu, Buenos Aires, AR, and Francesc Bosch, University Hospital Vall d'Hebron, Barcelona, ES, discussed how they would treat a patient with chronic lymphocytic leukemia (CLL) who has relapsed after treatment with venetoclax + rituximab.
Figure 1 illustrates the case of a patient with R/R CLL. The two speakers outline how they would move forward with this case, while presenting the latest data from relevant clinical trials in the R/R CLL setting.
Figure 1. R/R CLL patient case1
BM, bone marrow; CLL, chronic lymphocytic leukemia; ECOG, FISH, fluorescence in situ hybridization; IGHV, immunoglobulin heavy chain variable region; R/R, relapsed and/or refractory; WBC, white blood cell.
Latin American perspective: Astrid Pavlovsky
Astrid Pavlovsky began with an overview of the ethnic composition of Latin America and the prevalence of common B-cell non-Hodgkin lymphoma types in Central and South America. She then highlighted the lack of targeted therapies and diagnostic techniques in some Latin American countries.
When discussing the patient case, she first eliminated cellular therapy as a feasible option due to the patient’s age and comorbidities, as well as the limited availability of experimental therapies in Latin America. As a result, Astrid Pavlovsky recommended therapeutic intervention with a pathway inhibitor (Figure 2), specifically a Bruton’s tyrosine kinase (BTK) inhibitor, and presented data from the ELEVATE CLL R/R study, which compared ibrutinib versus acalabrutinib for the treatment of high-risk CLL.
Figure 2. Schematic of treatment options following relapse to chemoimmunotherapy2,3
Slide courtesy of Astrid Pavlovsky.
Watch Astrid Pavlovsky’s presentation below.