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An expert panel hosted by

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Sequencing immune-based therapies in B-cell malignancies

with Ulric Jäger, Sagar Lonial, and Krina Patel

Saturday, June 15 | 18:00-19:30 CEST

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Visual abstract | Ibrutinib + venetoclax in untreated WM

Jun 29, 2024
Learning objective: After reading this article, learners will be able to cite a new clinical development in Waldenström’s macroglobulinemia.

The Lymphoma Hub is please to present a visual abstract summarizing results from a phase II trial (NCT04273139) assessing the safety and efficacy of ibrutinib, a Bruton’s tyrosine-kinase inhibitor, in combination with venetoclax, a B-cell lymphoma 2 inhibitor, for the treatment of treatment-naïve patients with Waldenstrom macroglobulinemia. Results were published by Castillo et al.1 in Blood.

Although ibrutinib plus venetoclax was associated with a good response rate, there was a higher than expected rate of ventricular arrhythmia, leading to the early termination of the study.1

Visual abstract

To download this visual abstract as a pdf, click below.

Download here

  1. Castillo JJ, Branagan AR, Sermer D, et al. Ibrutinib and venetoclax as primary therapy in symptomatic, treatment-naïve Waldenström macroglobulinemia. 2024;143(7);582-591. DOI:10.1182/blood.2023022420

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