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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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The Lymphoma & CLL Hub is an independent medical education platform, sponsored by Beigene and Roche, and supported through educational grants from Bristol Myers Squibb, Ipsen Biopharmaceuticals, Pfizer, and Pharmacyclics LLC, an AbbVie Company and Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC. View funders.
On behalf of the International Waldenstrom's Macroglobulinemia Foundation (IWMF), the Lymphoma Hub was pleased to speak with Stephen Ansell, Mayo Clinic, Rochester, US, who chaired a discussion on: What constitutes refractory disease in the context of Waldenstrom's Macroglobulinemia (WM)? This discussion also featured Christian Buske, Monique Minnema, Sheeba Koshy Thomas, and Jorge J. Castillo.
What constitutes refractory disease in the context of WM?
The panel begins by discussing disease manifestations and measurable parameters prior to, and posttreatment as well as the challenges of refractory disease not being clearly defined. Castillo mentions the contradictions of those patients who display symptom improvements but show no actual response in IgM levels, and vice versa, as this challenges the diagnosis of refractory disease. Sheeba highlights that patients on fixed-duration therapies who display progressive shortening of response duration until new symptoms appear/symptom reoccurrence could be added into the refractory disease group. Minnema highlights the value of defining an achievement goal for each patient, particularly for M-protein related diseases where numbers may be more important than clinical presentation. Lastly, Buske emphasizes the importance of not defining patients with refractory disease too early, as improvements are commonly expected after ending treatment; assessing patients in a case-by-case scenario is imperative.
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