All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.

The Lymphoma Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

An expert panel hosted by

Customizing first-line BTK inhibitors for CLL

with Gilles Salles, Paolo Ghia, and Francesc Bosch

Wednesday, October 23, 2024
18:30-19:30 BST

Register now

This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.

  TRANSLATE

The Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.
2023-07-21T09:48:12.000Z

Answering the common challenges facing real-world CAR T-cell therapies

Jul 21, 2023
Share:
Learning objective: After reading this article, learners will be able to cite the common challenges facing CAR T-cell therapy and possible solutions in development.

Test your knowledge! Take our quick quiz before and after you read this article to find out if you improved your knowledge. Results help us to improve content and continually provide open-access education.

During the EHA 2023 Hybrid Congress, the Lymphoma Hub and Multiple Myeloma Hub held a joint satellite session on the ins and outs of CAR T cells in the real world.

Here, we share the presentation by Michael Hudecek, University Hospital Würzburg, Würzburg, DE, discussing answers to common challenges in CAR T-cell therapy.

In this presentation, Hudecek identifies limitations in patient access and inefficient manufacturing protocols as the main challenges currently restricting the scalability of CAR T-cell therapies (Figure 1), before highlighting some possible innovative answers (Figure 2). 

Figure 1.  The effect of limited patient access on CAR T-cell therapy for patients with DLBCL in Italy*

CAR, chimeric antigen receptor; DLBCL, diffuse large B-cell lymphoma; R/R, relapsed/refractory;
2L, second line.
*Adapted from Jommi, et al.1

 

Figure 2. The impact of centralized CAR T-cell manufacturing on wait times for CAR T-cell infusion* 

 

CAR, chimeric antigen receptor; PoC, point of care.
*Created with BioRender.com

Watch or download the presentation to learn more about the common challenges and solutions facing CAR T-cell therapy today, including:

  • The geographical disparities in CAR T-cell funding and research
  • The current progress towards, and future role of, artificial intelligence in streamlining the manufacturing process of CAR T-cell products
  • The implementation of virus-free gene transfer in current genetic transposition methodologies
  • In vivo CAR T-cell production using nanoparticle-encased gene transfer vectors

Key points

  • Limited patient access and logistical challenges in the manufacturing of CAR T-cell products are major barriers to the wider use of these therapies.
  • Access inequality to education and hands-on practice with CAR T-cell therapies between countries contributes to limited patient access.2
  • The current logistical challenges disrupting the scalability and patient access to CAR T-cell therapy are:
    • CAR T-cell manufacturing restricted to centralized facilities
    • Acquiring clinical grade lentiviral or gammaretroviral vectors
    • High cost of CAR T-cell therapy (between 253,000 and 319,000 USD per QALY)2
    • Inadequate US and EU reimbursement policies1,3,4.
  • Three key areas of CAR T-cell innovation are driving solutions to these challenges:
    • The integration of artificial intelligence into the infrastructure of ‘smart manufacturing hospitals’ to facilitate data management and provide decision support.
    • Virus-free gene transfer, to overcome the difficulties in acquiring suitable retroviral vectors.
    • The simplification of CAR T-cell manufacturing using in vivo gene transfer techniques.

Session slides

To download this presentation, click below.

Download here

This activity was supported through an educational grant from Bristol Myers Squibb. 

  1. Jommi C, Bramanti S, Pani M, et al. CAR T-cell therapies in Italy: patient access barriers and recommendations for health system solutions. Front Pharmacol. Online ahead of print. DOI:3389/fphar.2022.915342
  2. Cappell KM, Kochenderfer JN. Long-term outcomes following CAR T cell therapy: what we know so far. Nat Rev Clin Oncol. 2023;20(6):359-371. DOI: 1038/s41571-023-00754-1
  3.  CAR-T Therapy: Ensuring access to a revolutionary cancer treatment. American Society of Gene + Cell Therapy. https://asgct.org/global/documents/patient-ed-infographics/asgct-car-t-access_one-pager_2-22-21.aspx. Published, 2020. Accessed July 17, 2023.
  4. Hopfinger G, Rupp B, Greil R. Barriers to patient access of CAR T cell therapies in Austria.  2023;16:79-90. DOI: 10.1007/s12254-022-00859-w

Understanding your specialty helps us to deliver the most relevant and engaging content.

Please spare a moment to share yours.

Please select or type your specialty

  Thank you

Your opinion matters

HCPs, what is your preferred format for educational content on the Lymphoma Hub?
12 votes - 29 days left ...

Newsletter

Subscribe to get the best content related to lymphoma & CLL delivered to your inbox