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Question 1 of 2
What major changes have been made to the Austrian CAR T-cell Network algorithm from 2022 compared with 2019?
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B
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D
Video series
Here, we share a presentation by Ulrich Jӓger, Medical University of Vienna, Vienna, AT, on a case study to evaluate sequencing therapies for patients with high-risk diffuse large B cell lymphoma (DLBCL).
The Lymphoma Hub has previously covered sequencing therapies for patients with high risk DLBCL.
In this presentation, Jӓger shares a case study from 2019 of a 59-year-old female patient with DLBCL and the treatment decisions leading to chimeric antigen receptor (CAR) T-cell therapy, changes from 2019 to 2022 onwards in the algorithm for patients with DLBCL in clinical routine (Figure 1), and results in relapsed/refractory (R/R) patients with low-risk DLBCL treated with CAR T-cell therapy, presented at the European Hematology Association (EHA) 2023 Hydrid Congress (Figure 2).
Figure 1. Selection algorithm for patients with DLBCL in clinical routine: Austrian CAR T-cell Network*
*Adapted from Greinix, et al.1
Figure 2. Probability of OS and PFS of patients with R/R LBCL infused with commercial CAR T-cell compounds*
CAR, chimeric antigen receptor; CI, confidence interval; LBCL, large B-cell lymphoma; OS, overall survival; PFS, progression-free survival; R/R, relapsed/refractory
*Adapted from Rudzki, et al.2
†Data from 65 patients treated with axicabtagene ciloleucel or tisagenlecleucel.
Watch or download the presentation to learn more about the understanding of CAR T-cell therapy in patients with DLBCL, including:
This activity was supported through an educational grant from Bristol Myers Squibb.
References