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Glofit-GemOx vs R-GemOx for R/R DLBCL: Results from phase III STARGLO trial
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Results from the phase III STARGLO trial (NCT04408638) of Glofit-GemOx vs R-GemOx in patients with R/R DLBCL were published in The Lancet by Abramson et al.1 The primary efficacy endpoint was OS. |
| Key learnings |
| With a median follow-up of 11.3 months, OS was longer for Glofit-GemOx vs R-GemOx (HR, 0.59; 95% CI, 0.40–0.89; p = 0.011). |
| At a median follow-up of 20.1 months, the updated analysis showed that median OS (25.5 months vs 12.9 months; p = 0.0064) and median PFS (13.8 months vs 3.6 months; p < 0.0001) were higher for Glofit-GemOx vs R-GemOx. |
| Safety of Glofit-GemOx was consistent with the known safety profiles of the individual agents. AE rates were higher with Glofit-GemOx vs R-GemOx (100% vs 96%). CRS occurred in 44% of patients in the Glofit-GemOx group, and most were low grade (Grade 1, 31%; Grade 2, 10%; and Grade 3, 2%). |
| The efficacy and tolerable safety data from the phase III STRAGLO trial support the use of Glofit-GemOx in the treatment of patients with R/R DLBCL. |
Abbreviations: AE, adverse event; CI, confidence interval; CRS, cytokine release syndrome; DLBCL, diffuse large B-cell lymphoma; Glofit-GemOx, glofitamab plus gemcitabine and oxaliplatin; HR, hazard ratio; OS, overall survival; PFS, progression-free survival; R-GemOx, rituximab plus gemcitabine and oxaliplatin; R/R, relapsed/refractory.
- Abramson JS, Ku M, Hertzberg M, et al. Glofitamab plus gemcitabine and oxaliplatin (GemOx) versus rituximab-GemOx for relapsed or refractory diffuse large B-cell lymphoma (STARGLO): a global phase 3, randomised, open-label trial. The Lancet. 2024;404(10466):1940-1954. Online ahead of print. DOI: 10.1016/S0140-6736(24)01774-4
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