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GLOW trial: 5-year follow-up of first-line fixed-duration ibrutinib plus venetoclax in older adults with CLL/SLL
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The phase III GLOW trial (NCT03462719) assessed the safety and efficacy of first-line fixed-duration Ibr + Ven vs Clb + Obi in older adults with CLL/SLL.1 The Lymphoma Hub previously reported the 4-year follow-up outcomes from the GLOW trial. The 5-year follow-up results of this trial were presented at the SOHO 2024 Annual Meeting by Munir.1 |
| Key learnings |
| The estimated 54-month PFS rate was higher in the Ibr + Ven arm vs Clb + Obi arm (67% vs 20%; HR, 0.256). |
| OS was higher and sustained at 57 months in the Ibr + Ven arm vs Clb + Obi arm (HR, 0.453; p = 0.0038). |
| The need for second-line therapy was lower by 82% in the Ibr + Ven arm (HR, 0.185; 95% CI, 0.096–0.355; p < 0.0001). |
| Long-term data from the GLOW trial demonstrate the durable efficacy and tolerable safety profile of Ibr + Ven, supporting its use in older adults with CLL/SLL. |
Abbreviations: CI, confidence interval; Clb, chlorambucil; CLL, chronic lymphocytic leukemia; Ibr, ibrutinib; Obi, obinutuzumab; OS, overall survival; PFS, progression-free survival; SLL, small lymphocytic lymphoma; SOHO, Society of Hematologic Oncology; Ven, venetoclax.
- Munir T. First-line fixed-duration ibrutinib plus venetoclax versus chlorambucil plus obinutuzumab: Up to 5 years of follow-up from the GLOW study. Poster #CLL-487. Presented at: Society of Hematologic Oncology 2024 Annual Meeting; Sep 4–7, 2024; Houston, US.
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