All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
The lym Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the lym Hub cannot guarantee the accuracy of translated content. The lym and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Lymphoma & CLL Hub is an independent medical education platform, sponsored by AbbVie, BeOne Medicines, Johnson & Johnson, Roche, and Sobi, and supported through educational grants from Bristol Myers Squibb, Incyte, Lilly, and Pfizer. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View lym content recommended for you
On the 15th November 2019, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) recommended the approval of lenalidomide in combination with rituximab (R²) for the treatment of adult patients with relapsed/refractory (R/R) grade 1-3a follicular lymphoma (FL).1 R2 is a chemotherapy-free treatment regimen consisting of immunomodulating lenalidomide plus the anti-CD20 antibody rituximab. The combination was approved earlier this year by the U.S. Food and Drug Administration (FDA) for the treatment of patients with marginal zone lymphoma (MZL) and FL (read more here).
The positive opinion was based on the data from the multicentre phase III studies AUGMENT (NCT01938001) and MAGNIFY (NCT01996865). AUGMENT investigated the efficacy and safety of R2 in comparison with rituximab alone in 295 patients with R/R FL. The study reported improved median progression-free survival (PFS) with the R2 combination compared to the rituximab alone (39.4 months vs 14.1 months, respectively), a hazard ratio of 0.46, and the objective response rate (ORR) of 80% in patients with FL.2 Meanwhile, the MAGNIFY study explored the efficacy of R2 followed by maintenance with lenalidomide or rituximab in 370 patients with R/R FL, MZL, or mantle cell lymphoma.3 In patients with FL, the ORR was 74% and the median PFS was 30.2 months. Read the Lymphoma Hub’s coverage of the AUGMENT study and watch Mathias Rummel discussing the MAGNIFY trial.
References
Your opinion matters
Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?