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Mosunetuzumab for the treatment of high-risk, heavily pretreated R/R follicular lymphoma
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A subgroup analysis from the pivotal phase II GO29781 (NCT02500407) study of mosunetuzumab was presented at the EHA 2024 Congress by Sarit Assouline.1 This analysis primarily focused on outcomes among patients with high-risk, heavily pretreated R/R FL with ≥3 years of follow-up. Subgroups included patients with a history of POD24, patients receiving mosunetuzumab in the 3L vs 4L or later, and patients aged ≥65 years.1
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In the subgroup analysis, ORR rates were 78%, 74%, and 81% in the overall, non-POD24, and POD24 populations, respectively. |
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Rates of CR did not differ significantly across the subgroups, with the highest CR rate (68.6%) observed in patients treated with mosunetuzumab in the 3L (compared with 54.5% in patients treated in the 4L or later). |
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The 3-year PFS rate did not differ significantly between groups and was 43%, 44%, and 42% for the overall, non-POD24, and POD24 populations, respectively. |
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The 3-year OS rates were also similar across subgroups (83%, 81%, and 84% for the overall, non-POD24, and POD24 populations, respectively). |
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The safety profile for each subgroup, including in older patients aged ≥65 years, was largely consistent with that for the overall population. |
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Overall, fixed-duration mosunetuzumab resulted in consistently favorable outcomes across subgroups of patients with high-risk R/R FL, including those with POD24, and in older patients. Efficacy outcomes may be improved with mosunetuzumab use in earlier rather than later lines of treatment. |
Abbreviations: 3L, third-line; 4L, fourth-line; EHA, European Hematology Association; CR, complete response; FL, follicular lymphoma; OS, overall survival; PFS, progression-free survival; POD24, progression of disease within 24 months from the start of first-line therapy; R/R, relapsed/refractory.
- Assouline S. Mosunetuzumab demonstrates clinically meaningful outcomes in high-risk patients with heavily pre-treated R/R FL after ≥3 years of follow-up: Subgroup analysis of a pivotal phase II study. Oral abstract #233. European Hematology Association (EHA) 2024 Congress; Jun 13-17; Madrid, ES.
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