The virtual Lymphoma Hub Satellite Symposium at the European School of Haematology (ESH)’s 2nd How to Diagnose and Treat: Lymphoma conference saw a panel of international experts come together to discuss how to manage patients with relapsed and/or refractory (R/R) lymphoma. Kieron Dunleavy, George Washington University Cancer Center, Washington, US, and Marie José Kersten, Amsterdam UMC, Amsterdam, NL, discussed the progress being made in the field of R/R diffuse large B-cell lymphoma (DLBCL). Below you will find their perspectives as presented at the symposium.
The two panelists outlined their approaches to treating a distinct patient case (Figure 1) while highlighting the emerging strategies in the R/R DLBCL setting across Europe and the US.
Figure 1. R/R DLBCL patient case1
ASCT, autologous hematopoietic stem cell transplantation; CAR, chimeric antigen receptor; DHAP, dexamethasone + high-dose cytarabine + cisplatin; DLBCL, diffuse large B-cell lymphoma; ECOG, FISH, fluorescence in situ hybridization; IGHV, immunoglobulin heavy chain variable region; LDH, lactate dehydrogenase; R/R, relapsed and/or refractory; R-CHOP, rituximab + cyclophosphamide + doxorubicin + vincristine + prednisone.
US perspective: Kieron Dunleavy
Kieron Dunleavy began with a summary of what he considers to be feasible next steps for the patient following relapse to chimeric antigen receptor (CAR) T-cell therapy. He outlined recently approved agents and combination regimens, as well as therapies being evaluated in clinical trials. Dunleavy concluded with an emphasis on prognostic techniques, stressing the need for a biopsy to determine the patient’s CD19 expression profile. In terms of therapeutic approach, he suggested enrolling the patient onto a clinical trial evaluating novel bispecific antibodies.
Take part in the survey and watch Kieron Dunleavy’s presentation below.